What is Disintegration?
Disintegration is the vitro test which is performed using basket rack assembly to check the rate at which the tablet breaks down into small fragments.
The process in which solid dosage forms when come in contact with fluid breaks down into small granules of fragments which pass through the mesh no #10 or 2.0±0.2 mm leaving behind no solid mass.
Disintegration test is performed in vitro means outside the body to check that our tablets or solid dosage form breaks down properly into small fragments in a specified time period.
When we take a solid dosage form it should disintegrate properly inside the body to facilitate the process of drug release.
If we take a solid dosage form which does not disintegrate in the body will not produce the desired pharmacological effect.
The disintegration time can be adjusted using a class of excipients known as disintegrants and super disintegrants.
These disintegrants or super disintegrants break the bondings in solid dosage forms and facilitate the drug release.
What is disintegration time?
Disintegration time is the time required for a dosage form to break up in to granules of specified size (or smaller) under carefully specified conditions. ... In other words, DT (disintegration time) is measuring the breakdown of a dosage form and dissolution is measuring the drug being solubilized in the media.