Auto-Lifting Dissolution Tester
Auto-lifting Tablet dissolution tester, with LCD display.
The header move up and down automatically.
The preset and real data could displayed alternately in time, and the timing function could be preset
IQ/OQ documents included free of charge.
It is manufactured in compliance to the USP and EP.
For RC-6D
- It has 6 vessels and 6 poles arranged on one line.
- The head moves up/down automatically.
- The basket units and paddle units are made of imported stainless steel (SUS316L).
- The magnetism-pumped circular water current can heat the system evenly, and the bath liquid can achieve an equal temperature.
- A MPU is used in dissolution tester to automatically control the temperature, rotational speed and time, and the parameters can be preset at any time.
- It can be operated conveniently by keystroke. The measurement result is displayed and the preset and real data can be displayed alternately in time.
- Automation: auto-test, auto-diagnose, auto-alarm.
- It can test by self and alarm automatically. The dissolution parameters of' Chinese codex 2020' are stored in and can be taken out at anytime.
- Time can be preset at many points. The beeper sounds automatically to any point, and then the tester automatically runs to the next one.
For RC-8D
- It has 8 vessels and 6 poles, with 6 vessels and 6 poles in front, and 2 additional vessels at back for replacement media.
- The head moves up/down automatically.
- The basket units and paddle units are made of imported stainless steel (SUS316L).
- The magnetism-pumped circular water current can heat the system evenly, and the bath liquid can achieve an equal temperature.
- A MPU is used in dissolution tester to automatically control the temperature, rotational speed and time, and the parameters can be preset at any time.
- It can be operated conveniently by keystroke. The measurement result is displayed and the preset and real data can be displayed alternately in time.
- Automation: auto-test, auto-diagnose, auto-alarm.
- It can test by self and alarm automatically. The dissolution parameters of' Chinese codex 2020' are stored in and can be taken out at anytime.
- Time can be preset at many points. The beeper sounds automatically to any point, and then the tester automatically runs to the next one.
For RC-8DS
- It has 8 vessels and 8 poles, with 4 vessels and 4 poles in front and other at back.
- The head moves up/down automatically.
- The basket units and paddle units are made of imported stainless steel (SUS316L).
- The magnetism-pumped circular water current can heat the system evenly, and the bath liquid can achieve an equal temperature.
- A MPU is used in dissolution tester to automatically control the temperature, rotational speed and time, and the parameters can be preset at any time.
- It can be operated conveniently by keystroke. The measurement result is displayed and the preset and real data can be displayed alternately in time.
- Automation: auto-test, auto-diagnose, auto-alarm.
- It can test by self and alarm automatically. The dissolution parameters of' Chinese codex 2020' are stored in and can be taken out at anytime.
- Time can be preset at many points. The beeper sounds automatically to any point, and then the tester automatically runs to the next one.
For RC-12D
- The head moves up/down automatically.
- Available for installation of 12 basket shaft or paddles.
- Available for installation of 12 new dissolution vessels with height of 185mm and amber dissolution vessels for optional.
- Friendly human-computer interface, with simple and convenient operation.
- All the working parameters can be preset and saved automatically, without the need to set repeatedly when the instrument is started next time.
- Accurate rotating speed, steady operation and low energy consumption.
- Thermostatic water bath adopts built-in integrated temperature sensor and new software and hardware temperature measurement and control mode, which is featured by fast temperature rise and high precision; temperature deviation can be corrected with software conveniently.
- Independent operation of startup, pause and reset for experimental timing.
- Automatic protection functions such as self-inspection fault alarm and over-temperature protection, etc.
- The paddle rod, basket rod and basket turning body are all made of stainless-steel material meet the requirements of Chinese Pharmacopoeia in quality and performance.
| Model | RC-6D | RC-8D | RC-8DS | RC-12D |
| Testing Station | 6 | 6 | 8 | 12 |
| Speed Range | 20~200 rpm | 20~200 rpm | 20~200 rpm | 20~200 rpm |
| Speed Accuracy | ±2rpm | ±2rpm | ±2rpm | ±2rpm |
| Temperature Range | Rt~45.0°C | Rt~45.0°C | Rt~45.0°C | Rt~45.0°C |
| Temperature Stability | ±0.3°C | ±0.3°C | ±0.3°C | ±0.3°C |
| Preset Timing Nine Points | 5~900 min | 5~900 min | 5~900 min | 5~900 min |
| Time Accuracy | ±0.5 mm | ±0.5 mm | ±0.5 mm | ±0.5 mm |
| Paddle Radial Run-Out | ±0.5 mm | ±0.5 mm | ±0.5 mm | ±0.5 mm |
| Basket Radial Run-Out | ±1.0 mm | ±1.0 mm | ±1.0 mm | ±1.0 mm |
| Power Supply | 220V/ 50Hz, 110V/ 60Hz | 220V/ 50Hz, 110V/ 60Hz | 220V/ 50Hz, 110V/ 60Hz | 220V/ 50Hz, 110V/ 60Hz |
| Power | 1200W | 1200W | 1200W | 1200W |
| Dimension | 960×400×480 mm | 960×520×480 mm | 680×540×480 mm | 900×550×550 mm |
What is Dissolution?
Dissolution is a process in which dosage forms dissolve to form a solution and the amount of drug dissolved is determined by HPLC or other analytical methods.
Dissolution is a process in which a solute in the form of gas, liquid or solid form dissolves in a solvent to form a solution.
Explanation
The process of checking the rate at which drug dissolves in a liquid medium is known as dissolution.
When we take any dosage form orally it should properly dissolve in gastrointestinal fluid to release its active pharmaceutical ingredient and after proper dissolution of API it will reach the systemic circulation and its bioavailability will be increased.
To check the in vitro dissolution profile different types of dissolution apparatus are used for different dosage forms.
For solid dosage forms type 1 or type 2 dissolution apparatus are used where a tablet or capsule dissolves in the liquid medium and sampling of solution is done at specific time intervals to check the dissolution rate of drug
Disintegration VS Dissolution
| Disintegration | Dissolution |
| It is a Physical Test. | It is a Chemical Test. |
| This test is Used for solid dosage forms | This test is Used for solid dosage forms, gases and liquids. |
| In this test Solid dosage forms breaks down into small fragments | In this test Dosage forms dissolve to form solution |
| In-vitro | In-vitro & In-Vivo |
Relationship between Disintegration and Dissolution
Disintegration and dissolution are interrelated with each other.
There is an inverse relation between disintegration and dissolution.
If the disintegration time of solid dosage form is high the dissolution rate of that product will be low.
For getting a good dissolution profile the product should disintegrate rapidly.
Suppose we take a tablet and in the stomach, it does not properly disintegrate then its dissolution profile will be low and its bioavailability will also be low.