Manual Dissolution Tester (1/3 vessels)

What is Dissolution?

Dissolution is a process in which dosage forms dissolve to form a solution and the amount of drug dissolved is determined by HPLC or other analytical methods.

Dissolution is a process in which a solute in the form of gas, liquid or solid form dissolves in a solvent to form a solution.

Explanation

The process of checking the rate at which drug dissolves in a liquid medium is known as dissolution.

When we take any dosage form orally it should properly dissolve in gastrointestinal fluid to release its active pharmaceutical ingredient and after proper dissolution of API it will reach the systemic circulation and its bioavailability will be increased.

To check the in vitro dissolution profile different types of dissolution apparatus are used for different dosage forms.

For solid dosage forms type 1 or type 2 dissolution apparatus are used where a tablet or capsule dissolves in the liquid medium and sampling of solution is done at specific time intervals to check the dissolution rate of drug

Disintegration VS Dissolution

Relationship between Disintegration and Dissolution

Disintegration and dissolution are interrelated with each other.

There is an inverse relation between disintegration and dissolution.

If the disintegration time of solid dosage form is high the dissolution rate of that product will be low.

For getting a good dissolution profile the product should disintegrate rapidly.

Suppose we take a tablet and in the stomach, it does not properly disintegrate then its dissolution profile will be low and its bioavailability will also be low.