Tablet Four-Usage Tester
Lorderan Tablet Four-Usage Tester, with LCD display.
Multi-function to test the hardness, friability, disintegration time limit and dissolution rate.
SUS 316L stainless steel is adopted for dissolution rotation baskets and paddle rods, etc.
Tablet for hardness test is pressed automatically.
IQ/OQ documents included free of charge.
It is manufactured in compliance to the USP and EP

- Smart, automatic control, automatic detection, automatic diagnosis and automatic alarm.
- Magnetic water pump circulating water flow uniform heat system is adopted, bath temperature is uniform.
- Automatic temperature control and high temperature control precision.
- Automatic time control and automatic timing shutdown.
- Parameters can be preset arbitrarily; preset value and real-time value can be displayed by time division.
- The three dissolution cups and three rods are in a single row; the head part can be turned over manually, it’s steady and flexible.
- Imported SUS316L stainless steel is adopted for dissolution rotation baskets and paddle rods, etc.
- Two-path disintegration operates at the same time, automatic timing shutdown.
- Automatic control of friability and high control precision for cylinder rotation speed and number of turns.
- Hardness high-precision pressure sensor, digital display of hardness value.
- Continuous measurement of tablet hardness value, manual tablet feeding, motor control and automatic compression.
- Automatic display, automatic latching, automatic reset and automatic cyclic test.
Model | PJ-4D | PJ-6D |
Testing Parameter | Hardness, Friability, Disintegration, Dissolution | Hardness, Friability, Disintegration, Dissolution |
Temperature Range | 20~40 °C, ±0.3 °C | 20~40 °C, ±0.3 °C |
Speed Range | 20~200 rpm ±2 rpm | 20~200 rpm ±2 rpm |
Timing Range | 1~900 min ±0.5 min | 1~900 min ±0.5 min |
Paddle Radial Run-Out | ±0.5 mm | ±0.5 mm |
Basket Radial Run-Out | ±1.0 mm | ±1.0 mm |
Centering | ±2.0 mm | ±2.0 mm |
Dissolution | 3 | 6 |
Nacelles | 2 | 2 |
Nacelle Glass Tubes | 6 | 6 |
Volume Of The Beaker | 1000 ml | 1000 ml |
Nacelle Up And Down Frequency | 30~32/min | 30~32/min |
Nacelle Up And Down Range | 55±1 mm | 55±2 mm |
Drum | 1 | 2 |
Drum’s Radius | Dia. 286 mm | Dia. 286 mm |
Drum’s Depth | 39 mm | 39 mm |
Tablet Falling Height | 156 mm | 156 mm |
Rotation Count | 100 r | 100 r |
Rotation Speed | 25 rpm | 25 rpm |
Speed Regulator Accuracy | ±1 rpm | ±1 rpm |
Hardness Range | 2~199.9N (50Kg, 499.9N is optional) | 2~199.9N (50Kg, 499.9N is optional) |
Probe Procession Range | 3~40 mm | 3~40 mm |
Power Supply | 220V/ 50Hz, 110V/ 60Hz | 220V/ 50Hz, 110V/ 60Hz |
Power | 500W | 600W |
Dimension | 580×380×470 mm | 580×520×470 mm |
Weight | 31 Kg | 42 Kg |
What is Dissolution?
Dissolution is a process in which dosage forms dissolve to form a solution and the amount of drug dissolved is determined by HPLC or other analytical methods.
Dissolution is a process in which a solute in the form of gas, liquid or solid form dissolves in a solvent to form a solution.
Explanation
The process of checking the rate at which drug dissolves in a liquid medium is known as dissolution.
When we take any dosage form orally it should properly dissolve in gastrointestinal fluid to release its active pharmaceutical ingredient and after proper dissolution of API it will reach the systemic circulation and its bioavailability will be increased.
To check the in vitro dissolution profile different types of dissolution apparatus are used for different dosage forms.
For solid dosage forms type 1 or type 2 dissolution apparatus are used where a tablet or capsule dissolves in the liquid medium and sampling of solution is done at specific time intervals to check the dissolution rate of drug
Disintegration VS Dissolution
Disintegration | Dissolution |
It is a Physical Test. | It is a Chemical Test. |
This test is Used for solid dosage forms | This test is Used for solid dosage forms, gases and liquids. |
In this test Solid dosage forms breaks down into small fragments | In this test Dosage forms dissolve to form solution |
In-vitro | In-vitro & In-Vivo |
Relationship between Disintegration and Dissolution
Disintegration and dissolution are interrelated with each other.
There is an inverse relation between disintegration and dissolution.
If the disintegration time of solid dosage form is high the dissolution rate of that product will be low.
For getting a good dissolution profile the product should disintegrate rapidly.
Suppose we take a tablet and in the stomach, it does not properly disintegrate then its dissolution profile will be low and its bioavailability will also be low.