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|Testing Parameter||Hardness, Friability, Disintegration, Dissolution||Hardness, Friability, Disintegration, Dissolution|
|Temperature Range||20~40 °C, ±0.3 °C||20~40 °C, ±0.3 °C|
|Speed Range||20~200 rpm ±2 rpm||20~200 rpm ±2 rpm|
|Timing Range||1~900 min ±0.5 min||1~900 min ±0.5 min|
|Paddle Radial Run-Out||±0.5 mm||±0.5 mm|
|Basket Radial Run-Out||±1.0 mm||±1.0 mm|
|Centering||±2.0 mm||±2.0 mm|
|Nacelle Glass Tubes||6||6|
|Volume Of The Beaker||1000 ml||1000 ml|
|Nacelle Up And Down Frequency||30~32/min||30~32/min|
|Nacelle Up And Down Range||55±1 mm||55±2 mm|
|Drum’s Radius||Dia. 286 mm||Dia. 286 mm|
|Drum’s Depth||39 mm||39 mm|
|Tablet Falling Height||156 mm||156 mm|
|Rotation Count||100 r||100 r|
|Rotation Speed||25 rpm||25 rpm|
|Speed Regulator Accuracy||±1 rpm||±1 rpm|
|Hardness Range||2~199.9N (50Kg, 499.9N is optional)||2~199.9N (50Kg, 499.9N is optional)|
|Probe Procession Range||3~40 mm||3~40 mm|
|Power Supply||220V/ 50Hz, 110V/ 60Hz||220V/ 50Hz, 110V/ 60Hz|
|Dimension||580×380×470 mm||580×520×470 mm|
|Weight||31 Kg||42 Kg|
What is Dissolution?
Dissolution is a process in which dosage forms dissolve to form a solution and the amount of drug dissolved is determined by HPLC or other analytical methods.
Dissolution is a process in which a solute in the form of gas, liquid or solid form dissolves in a solvent to form a solution.
The process of checking the rate at which drug dissolves in a liquid medium is known as dissolution.
When we take any dosage form orally it should properly dissolve in gastrointestinal fluid to release its active pharmaceutical ingredient and after proper dissolution of API it will reach the systemic circulation and its bioavailability will be increased.
To check the in vitro dissolution profile different types of dissolution apparatus are used for different dosage forms.
For solid dosage forms type 1 or type 2 dissolution apparatus are used where a tablet or capsule dissolves in the liquid medium and sampling of solution is done at specific time intervals to check the dissolution rate of drug
Disintegration VS Dissolution
It is a Physical Test.
It is a Chemical Test.
This test is Used for solid dosage forms
This test is Used for solid dosage forms, gases and liquids.
In this test Solid dosage forms breaks down into small fragments
In this test Dosage forms dissolve to form solution
In-vitro & In-Vivo
Relationship between Disintegration and Dissolution
Disintegration and dissolution are interrelated with each other.
There is an inverse relation between disintegration and dissolution.
If the disintegration time of solid dosage form is high the dissolution rate of that product will be low.
For getting a good dissolution profile the product should disintegrate rapidly.
Suppose we take a tablet and in the stomach, it does not properly disintegrate then its dissolution profile will be low and its bioavailability will also be low.